Welcome to the CreakyJoints Pharmacopeia. Whether you're curious about a new prescription from your doctor or just want to learn a little more about the specific drug you're taking, this is the site for you! We have a detailed description of over 25 different drugs and we are steadily building on our collection. We want to provide you with up to date information that will help make you more aware of your condition and drug intake.

What is a Nonsteroidal Anti-Inflammatory Drug (NSAID)?

Nonsteroidal anti-inflammatory drugs are usually abbreviated as NSAID. From here on in, you'll be seeing these types of drugs referred to as NSAIDs. NSAIDs are very well tolerated by our bodies, and are often the initial therapy for common inflammation. That's why they're great for arthritis! They can also be used to help cope with a muscle strain or sprain, high fevers and general pain we can acquire from overworking or overexerting out bodies on a daily basis.


How do NSAIDs work?
NSAIDs block or inhibit the body's inflammation process without the use of cortisone or other steroid drugs. Inflammation is one of the body's healing responses to trauma. Steroids and drugs that contain steroids combat inflammation by suppressing the immune system. All NSAIDs treat inflammation in a way similar to the mechanism of aspirin, the most well known and oldest member of the class. NSAID drugs mainly inhibit the body's ability to synthesize prostaglandins. Prostaglandins are a family of hormone-like chemicals, some of which are made in response to cell injury. The common mechanism of action for all NSAIDs is the inhibition of the enzyme cyclooxgenase (COX). COX is necessary in the fomation of prostaglandins. This enzyme actually has two known forms, COX-1 which protects the stomach lining and intestine, and COX-2 which is involved in making the prostaglandins that are important in the process of inflammation.

Most NSAIDs currently available inhibit both COX-1 and 2. The COX-1 inhibition is associated with the warning that stomach irritation, ulcers and internal bleeding can occur without notice. COX-2 inhibitors stop the formation of prostaglandins responsible for pain, fever and inflammation. Most people tolerate the nonspecific NSAIDs but a group of people with gastric complaints, or who have had liver, kidney or heart problems in the past are more likely to develop ulcers and stomach irritation. A new family of drugs, called COX II inhibitors isolates only COX-2, therefore minimizing the chance of the original side effects. COX II inhibitors are available in the US by prescription only. On another positive note, all COX inhibitors have been reported to have a protective effect against colon cancer and Alzheimer's disease.


What is a COX II inhibitor?
COX II inhibitors are a new family of nonsteroidal anti-inflammatory drugs (NSAIDs). Just because they are new, don't assume they're more effective at reducing inflammation and pain. The only main difference between COX II inhibitors and their older, traditional NSAIDs is that they are believed to cause less stomach irritation. However, they are still classified as NSAIDs.

There is a theory about COX II inhibitors, though not yet proven. Some scientists believe that their use is associated with an increased risk of cardiovascular events such as heart attack. You should voice any concerns or additional questions to your doctor.


Are there any general side effects from taking NSAIDs?
Yes. NSAIDs may upset your stomach and cause nausea and vomiting. To prevent this, do not take these drugs on an empty stomach. After a meal and with a full glass of water would be your best bet to avoid any unwelcome situations. Even a glass of milk or a small snack is adequate. Long-term or extensive ingestion of NSAIDs can result in or increase the risk of the drugs having toxicity to the kidneys and also to the lining of the stomach, possibly causing ulcers.


Nonsteroidal Anti-Inflammatory Drug Precautions
All NSAID drugs have the potential to cause irritation, ulceration, bleeding and perforation of the lining of the stomach. To avoid this risk, never take any NSAID drug on an empty stomach. NSAID's should be taken after a meal to minimize the chances of these side effects.

- Mixing Coumadin (Warfarin Sodium) with NSAID drugs such as aspirin or ibuprofen can cause serious complications.
- Do not mix any NSAID drug with blood-thinners such as Coumadin (Warfarin Sodium) unless your doctor gives you specific instructions on how to do so.
- Some NSAID drugs have been known to cause drowsiness. Ask your doctor or pharmacist for their opinion and recommendations regarding this matter.


What about Drug Interactions?
NSAID drugs are good to take because of the few drug interactions they have. Some researchers feel that NSAIDs can weaken the effect of certain blood-pressure medications.

Anaprox (Naproxen Sodium)
Pronounced: AN-uh-procks
Drug Family = Arylacetic Acid; Roche

Prescribed for: An NSAID used to relieve mild to moderate pain and menstrual cramps. It is also prescribed for relief of the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis, and for ankylosing spondylitis, tendinitis, bursitis, acute gout, and for juvenile arthritis.
How should I take this drug? Take regularly for arthritis relief. If you miss a dose, take forgotten does within the same day but do not take two doses at the same time.
Over the counter forms: Aleve, Naprelan.
Side effects: To avoid stomach upsets, take with a glass of water or with a meal. May also occur- abdominal pain, bruising, constipation, diarrhea, difficult or labored breathing, dizziness, drowsiness, headache, hearing disturbances, heartburn, indigestion, inflammation of the mouth, itching, light-headedness, nausea, rapid, fluttery heartbeat, red or purple spots on the skin, ringing in the ears, skin eruptions, sweating, and swelling due to fluid retention.
Special warnings: Can increase water retention. It also may cause vision problems. Do not take if you are allergic to Aspirin or Motrin, or have had hives or asthma attacks as a result of taking these or other related drugs. Peptic ulcers and internal bleeding can occur without warning. Do not take with any of the following: Aspirin; other pain relievers such as acetaminophen (Tylenol), and ibuprofen (Motrin); ACE inhibitors such as the blood pressure medication Capoten; Antiseizure drugs such as Dilantin; Beta blockers, including blood pressure drugs such as Inderal; Lithium (Lithonate); Methotrexate; Naproxen in other forms, such as Naprosyn; Blood thinners such as Coumadin; Certain water pills (diuretics) such as Lasix; Oral diabetes drugs such as Micronase; Probenecid (Benemid).

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Ansaid (Flurbiprofen)
Pronounced: AN-sed
Drug Family = Phenylalkanoic Acid Derivative; Pharmacia

Prescribed for: An NSAID used for the relief of signs and symptoms of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, pain associated with dysmenorrhea, and pain accompanied by inflammation (e.g., bursitis, tendinitis, soft-tissue trauma).
How should I take this drug? With food or antacid, follow instructions from doctor. For arthritis relief, take regularly. If you miss a dose, take forgotten does within the same day but do not take two doses at the same time.
Side effects: Ulceration, perforation and bleeding of the stomach, small intestine, and large intestine. Elderly (particularly women) are at higher risk, lower dosage recommended. Abdominal pain, diarrhea, general feeling of illness, headache, indigestion, nausea, swelling due to fluid retention, urinary tract infection may occur. Can also increase water retention.
Special warnings: Consult a doctor if you have asthma and do not take if you have ASA-sensitive asthma. Take with caution if you have a liver or kidney disease, heart disease or high blood pressure. Side effects may increase or alter when this drug is combined with any of the following: Antacids; Aspirin; Beta blockers such as the blood pressure medications Inderal and Tenormin; Blood thinners such as Coumadin; Cimetidine (Tagamet); Methotrexate (Rheumatrex); Ranitidine (Zantac); Water pills such as Lasix and Bumex; Oral diabetes drugs such as Micronase.

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Arthrotec (Diclofenac Sodium + Misoprostil)
Pronounced: ARE-throw-teck
Drug Family = Benzeneacetic acid Derivative plus Syntheric Prostaglandin E1 Analogue; Searle

Prescribed for: The relief of arthritis in those prone to ulcers. Contains both an NSAID (Diclofenac) to control inflammation, stiffness, swelling, and other joint pain associated with rheumatoid arthritis and osteoarthritis. Since NSAIDs may cause ulcers, Misoprostil (a synthetic prostaglandin) is combined with Diclofenac to reduce the production of stomach acid and protect the stomach lining, ultimately preventing ulcers.
How should I take this drug? Take tablets whole, do not chew or crush. Take with a meal or with an antacid that does not contain magnesium because it can increase the side effects. Preferably, use an antacid that contains aluminum or calcium. For arthritis relief, take regularly. If you miss a dose, take forgotten does within the same day but do not take two doses at the same time.
Side effects: Abdominal pain, acid indigestion, diarrhea, gas, nausea, abnormal vision or tearing. May still cause ulcers.
Special warnings: Do not take during pregnancy, it will cause severe fetal harm. Avoid if you have had a past reaction to prostaglandin medication, or to any NSAID, including aspirin. Use with caution if you have systemic lupus or a similar connective tissue disease, porphyria, kidney problems or liver disease. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Glyburide (Diabeta, Micronase); Insulin; Blood pressure medications such as Cardizem, Inderal, Procardia, and Vasotec; Cyclosporine (Neoral, Sandimmune); Glipizide (Glucotrol, Glucotrol XL); Lithium (Lithobid, Lithonate); Magnesium-containing antacids such as Maalox and Mylanta; Methotrexate (Rheumatrex); Phenobarbital; Prednisolone (Delta-Cortef, Pediapred, Prelone); Warfarin (Coumadin); Digoxin (Lanoxin); Diuretics (Lasix, HydroDIURIL).
Official Website

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Bextra (valdecoxib; pharmacia)
Pronounced: BEK-struh
Drug Family = Cox II

Prescribed for: A COX-2 inhibitors that relieves pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and menstruation (dysmenorrhea). This drug as well as other COX-2 inhibitors, limits the effect of a natural enzyme called COX-2. They do not interfere with COX-1, an enzyme that yields a protective effect on the lining of the stomach like the older NSAIDs did. Because of this, Bextra and other COX-2 inhibitors are less likely to cause the bleeding and ulcers that can occur from the continuous use of older NSAIDs.
How should I take this drug? With food or an antacid. For arthritis relief, take regularly or as directed by your doctor. If you miss a dose, take forgotten does within the same day. Never take two doses at the same time.
Side effects: Headache, abdominal pain, headache, indigestion, nausea, diarrhea, swelling in the hands and feet, upper respiratory infection, stomach discomfort or abnormal, bloody, black, tarry stools. Severe stomach pain is more prone in people who have previously had ulcers or bleeding in the past.
Special warnings: If you have been taking other medications such as steroids for arthritis, do not stop abruptly unless instructed to do so by your doctor. If you have high blood pressure or heart problems use with caution, can cause water retention. Can trigger asthma attacks. Long-term use can injure kidneys; particularly if you have had past kidney problems. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; blood pressure medications known as ACE inhibitors, including Capoten, Lotensin, and Vasotec; Cough medications containing dextromethorphan, such as Benylin and Robitussin Honey Cough; Fluconazole (Diflucan); Ketoconazole (Nizoral); Lithium (Eskalith, Lithobid); Warfarin (Coumadin); Water pills (diuretics) such as Lasix and HydroDIURIL.
Official Website

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Cataflam also Voltaren (Diclofenac Potassium)
Pronounced: vol-TAR-en
Drug Family = Benzeneacetic acid Derivative; Novartis
Prescribed for: An NSAID for the relief of acute and chronic treatment of signs and symptoms associated with osteoarthritis and rheumatoid arthritis, the treatment of ankylosing spondylitis and general pain, stiffness, swelling, and inflammatory conditions. It can also be prescribed for the immediate relief of pain and menstrual discomfort.
How should I take this drug? Directly after a meal or with a snack, milk, or an antacid, it should also be taken with a full glass of water. Drug is usually taken 3 times a day. Taking on an empty stomach can cause gastric discomfort. To prevent irritation in upper digestive track, do not lie down or sleep for at least 20 minutes after taking dose. If you miss a dose, take forgotten does within the same day but do not take two doses at the same time.
Side effects: Abdominal pain or cramps, constipation, diarrhea, headache, indigestion, and nausea.
Special warnings: Have frequent checkups if drug is taken regularly, ulcers or internal bleeding can occur without warning. Do not take if you have had past allergic reactions to Diclofenac, aspirin or an NSAID. May cause fluid retention, use with caution if you have previously had kidney problems, heart disease, or high blood pressure. Contact doctor if you develop vision problems, meningitis, or liver problems (signs: flu-like symptoms, nausea, fatigue, lethargy, itching, yellowish eyes and skin, or tenderness in the upper right area of your abdomen). Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Blood thinners such as Coumadin; Cyclosporine (Sandimmune); Digitalis drugs such as Lanoxin; Diuretics such as Dyazide, Midamor, and Lasixp; Insulin or oral antidiabetes medications such as Micronase; Lithium (Eskalith, Lithobid); Methotrexate; Phenobarbital.

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Celebrex (Celecoxib)
Pronounced: SELL-eh-breks
Drug Family = COXII Inhibitors; Pharmacia

Prescribed for: A COX-2 inhibitors that relieves pain and inflammation associated with osteoarthritis, rheumatoid arthritis. This drug as well as other COX-2 inhibitors, limits the effect of a natural enzyme called COX-2. They do not interfere with COX-1, an enzyme that yields a protective effect on the lining of the stomach as the older NSAIDs had. Because of this, Celebrex and other COX-2 inhibitors are less likely to cause the bleeding and ulcers that can occur from the continuous use of older NSAIDs. It also helps regulate normal cell function in the stomach and in the blood, reduce arthritis pain and inflammation as well as the number of colorectal polyps in people who suffer from familial adenomatous polyposis (FAP).
How should I take this drug? Can be taken with or without food.
Side effects: Headache, nausea, indigestion, diarrhea respiratory infection, sinus inflammation and abdominal pain. Severe stomach pain and ulcers may still develop, but is more prone in people who have previously had ulcers or gastrointestinal bleeding in the past.
Special warnings: Do not take if you have had or still have allergic reactions to sulfonamide drugs (sulfadiazine, sulfisoxazole, Gantanol, Thiosulfil). Avoid if you have or still have asthma attacks, face and throat swelling, skin eruptions from Aspirin or other NSAID's. If you have been taking other medications such as steroids for arthritis, do not stop abruptly unless instructed to do so by your doctor. Can cause water retention, use with caution if you have had past liver problems, heart disease, and high blood pressure. Known to cause liver and kidney problems. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; ACE-inhibitors (a type of blood pressure and heart medication, including such drugs as Capoten, Vasotec, and Prinivil); Blood thinning agents such as Coumadin; Fluconazole (Diflucan); Furosemide (Lasix); Lithium (Eskalith, Lithobid); Thiazide diuretics (water pills) such as hydrochlorothiazide and Dyazide.
Official Website

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Clinoril (Sulindac)
Pronounced: CLIN-or-il
Drug Family = Indene Derivative; Merck

Prescribed for: An NSAID to relieve inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Also used to treat bursitis, tendinitis, and acute gouty arthritis.
How should I take this drug? Take regularly for arthritis.
Side effects: Abdominal pain, constipation, diarrhea, dizziness, gas, headache, indigestion, itching, loss of appetite, nausea, nervousness, rash, ringing in ears, stomach cramps, swelling due to fluid retention, and vomiting.
Special warnings: Stomach ulcers and internal bleeding can occur without warning, more prone in those older than 65 and with poor kidney function. May cause poor vision, pancreatitis, drowsiness, an increase in water retention, or liver inflammation. Use with caution if you have kidney or liver disease, high blood pressure, or heart disease. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; blood thinners such as Coumadin; Cyclosporine (Sandimmune); Diflunisal (Dolobid); Dimethyl sulfoxide (DMSO); Lithium; Loop diuretics such as Lasix; Methotrexate; Oral diabetes medications; Other NSAID's (Aleve, Motrin, others); The anti-gout medication Benemid.

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Daypro (Oxaprozin)
Pronounced: DAY-pro

Prescribed for: An NSAID prescribed for the swelling, inflammation, stiffness and joint pain associated with osteoarthritis and rheumatoid arthritis. Eases mild to moderate pain and reduces fever.
How should I take this drug? Take with a full glass of water and to avoid an upset stomach, and with food, milk or an antacid. Take at the same time every day; if you forget a dose but remember within the same day then take it. Otherwise skip the does and return to the normal schedule, do not take two doses together.
Side effects: Headache, nausea, dizziness, drowsiness, gas, constipation, indigestion, and rash. May cause you to become sensitive to sunlight.
Special warnings: Ulcers or internal bleeding can occur without warning. May cause an increase in water retention or liver inflammation. Use with caution if you have kidney or liver disease, high blood pressure, heart disease, asthma or allergic reactions to aspirin or other NSAID's. Can prolong bleeding; do not take if you are going to have surgery. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Beta-blocking blood pressure medications such as Inderal and Tenormin; Blood thinners such as Coumadin; Digitalis and digoxin (Lanoxin); Diuretics such as Lasix and Midamor; Lithium (Lithonate); Ulcer drugs such as Tagamet and Zantac.

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Disalcid (Salsalate)
Pronounced: dye-SAL-sid
Drug Family = Salicylate; 3M

Prescribed for: An NSAID prescribed for the relief of symptoms associated with rheumatoid arthritis, osteoarthritis, and other rheumatic disorders. Mild to moderate pain relief of swelling, inflammation, stiffness, and joint pain.
How should I take this drug? Take regularly for arthritis. Take with food to avoid an upset stomach. If you miss a dose, take forgotten does within a few hours but do not take two doses at or around the same time.
Side effects: Hearing impairment, nausea, rash, ringing in the ears, or vertigo. Alert doctor if you develop bloody urine; diarrhea (severe or continuing); difficulty in swallowing; dizziness, lightheadedness or severe feeling faint; hallucinations; increased thirst; vomiting (severe or continuing); shortness of breath, troubled breathing, tightness in chest, or wheezing; stomach pain (severe or continuing); swelling of eyelids, face, or lips; uncontrollable flapping movements of hands; unexplained fever; or vision problems.
Special warnings: Do not take if you have flu symptoms or chickenpox. Use with caution if you have or have had chronic kidney disease or peptic ulcer, asthma or an allergic reaction to aspirin. Side effects may increase or alter when this drug is combined with any of the following: Aspirin and other drugs that contain salicylates (Bufferin, Empirin); ACE inhibitor-type blood pressure drugs such as Capoten and Vasotec; Acetazolamide (Diamox); Blood-thinning medications such as Coumadin; Medications for gout such as Zyloprim and Benemid; Methotrexate (Rheumatrex); Naproxen (Anaprox, Naprosyn); Oral diabetes drugs such as Glucotrol and Tolinase; Penicillin (Pen-Vee K); Phenytoin (Dilantin); Steroids such as Deltasone and Decadron; Sulfinpyrazone (Anturane); Thyroid medications such as Synthroid; alcohol.

Dolobid (Diflunisal)
Pronounced: DOLL-oh-bid
Drug Family = Salicylate; Merck

Prescribed for: An NSAID prescribed for the relief of inflammation, swelling, stiffness and join pain associated with rheumatoid arthritis and osteoarthritis, musculoskeletal trauma, and post-dental extraction or post-episiotomy.
How should I take this drug? Take regularly for arthritis. Do not take on an empty stomach. Take with food, drink (full glass of water or milk) or an antacid. Do not chew or crush tablet. If you miss a dose, take forgotten does within the same day but do not take two doses at the same time.
Side effects: Abdominal pain, drowsiness or sleepiness, constipation, diarrhea, dizziness, fatigue, gas, headache, inability to sleep, indigestion, nausea, rash, ringing in ears, and vomiting.
Special warnings: Ulcers and internal bleeding can occur without warning. Use with caution if you have or have had chronic kidney or liver disease, asthma, urticaria, or an allergic reaction to aspirin, high blood pressure or heart disease. This drug may cause water retention. May also cause poor vision or prolonged vision. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Acetaminophen (Tylenol); antacids taken regularly; Cyclosporine (Sandimmune); Methotrexate (Rheumatrex); oral anticoagulants (blood thinners); another NSAIDs (Advil, Motrin, Naprosyn, etc.); the arthritis medication sulindac (Clinoril); diuretic hydrochlorothiazide.

EC Naprosyn (Naproxen Sodium)
Drug Family = Arylacetic Acid Derivative; Roche

Same active ingredient as Naprosyn except tablet has a special coating to protect stomach.
See Naprosyn

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Feldene (Piroxicam)
Pronounced: FELL-deen
Drug Family = Oxicam; Pfizer

Prescribed for: An NSAID prescribed for the relief of swelling, inflammation, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis.
How should I take this drug? Take regularly for arthritis. Take with food or drink to avoid an upset stomach. If you miss a dose, take forgotten does within the same day but do not take two doses at the same time.
Side effects: Abdominal pain or discomfort, anemia, constipation, diarrhea, dizziness, fluid retention, gas, flue like symptoms, headache, heartburn, itching, loss of appetite, nausea, rash, ringing in ears, sleepiness, stomach ulcers or bleeding, stomach upset, vertigo, and vomiting.
Special warnings: If you develop severe abdominal or stomach cramps, pain or burning in the stomach, and black, tarry stools contact your doctor, it may be a sign of a stomach ulcer or internal bleeding. Use with caution if you have or have had chronic kidney or liver disease, asthma or an allergic reaction to aspirin, high blood pressure or heart disease (can increase water retention). Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Anticoagulants (blood thinners such as Coumadin); Blood pressure medications (ACE inhibitors, including Accupril, Altace, Mavik, Prinivil, and Zestril); Furosemide (Lasix); Lithium (Lithobid, Lithonate); Methotrexate (Rheumatrex); Thiazide-type water pills such as HydroDIURIL.

Indocin, Indocin SR (Indomethacin)
Pronounced: IN-doh-sin
Drug Family = Indole Derivative; Merck

Indocin SR is a sustained release version of Indocin.
Prescribed for: An NSAID used to relieve the inflammation, swelling, stiffness and joint pain associated with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Also used to treat bursitis, tendinitis, and acute gouty arthritis.
How should I take this drug? Take regularly for arthritis. Do not take on an empty stomach. Take with food or an antacid and do not lie down or sleep for at least 25 minutes after taking dose. If you miss a dose, take forgotten does within the same day but do not take two doses at the same time.
Side effects: Abdominal pain, constipation, depression, diarrhea, dizziness, fatigue, headache, heartburn, indigestion, nausea, ringing in the ears, sleepiness or excessive drowsiness, stomach pain, stomach upset, vertigo, or vomiting.
Special warnings: Ulcers or internal bleeding can occur without warning, particularly in those over 65 years. Use with caution if you have or have had chronic kidney or liver disease, asthma or an allergic reaction to aspirin, high blood pressure or heart disease (can increase water retention). Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Beta-blockers such as the blood pressure medications Tenormin and Inderal; Blood-thinning medicines such as Coumadin; Captopril (Capoten); Cyclosporine (Sandimmune); Diflunisal (Dolobid); Digoxin (Lanoxin); Lithium (Eskalith); Loop diuretics (Lasix); Other nonsteroidal anti-inflammatory drugs such as Advil, Aleve, and Motrin; Potassium-sparing water pills (Aldactone; Probenecid, Benemid, ColBENEMID); the anticancer drug methotrexate; Thiazide-type water pills such as Diuril; Triamterene (Dyazide).

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Lodine, Lodine XL (Etodolac)
Pronounced: LOW-deen
Drug Family = Pyranocarboxylic Acid Deriv; Wyeth

Lodine XL is a long acting version of Lodine.
Prescribed for: An NSAID used to relieve the inflammation, swelling, stiffness and joint pain associated with rheumatoid arthritis and osteoarthritis. Available in two forms, extended release (Lodine XL) and regular (Lodine).
How should I take this drug? Take regularly for arthritis. Do not take on an empty stomach. Take with food, drink (full glass of water) or an antacid. If you miss a dose, take forgotten does within the same day but do not take two doses at the same time.
Side effects: Abdominal pain, black stools, blurred vision, chills, constipation, depression, diarrhea, dizziness, fever, gas, increased frequency of urination, indigestion, itching, nausea, nervousness, rash, ringing in ears, painful or difficult urination, vomiting, or a developing weakness in strength.
Special warnings: Ulcers and internal bleeding can occur without warning. May cause you to develop anemia or poor vision. Use with caution if you have or have had chronic kidney or liver disease, asthma or an allergic reaction to aspirin, high blood pressure or heart disease (can increase water retention). Avoid if you have or still have asthma attacks, face and throat swelling, skin eruptions from Aspirin or other NSAID's. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Cyclosporine (Sandimmune, Neoral); Digoxin (Lanoxin); Lithium (Lithobid, others); Methotrexate; Phenylbutazone (Butazolidin); the blood-thinning drug warfarin (Coumadin).

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Mobic (Meloxicam)
Pronounced: MOH-bik
Drug Family = Oxicam Derivatine; Boehringer Ingelheim

Prescribed for: An NSAID used to relieve inflammation, swelling, stiffness and joint pain associated with osteoarthritis in adults.
How should I take this drug? Can be taken with or without food. Take regularly for arthritis and try to take drug at the same time each day.
Side effects: Diarrhea, upper respiratory tract infection, stomach pain, flu-like symptoms, indigestion, or nausea.
Special warnings: Do not take if you have or have had asthma, hives, or allergic-type reactions to aspirin or other NSAIDs (ibuprofen, naproxen, diclofenac, nabumetone, ketoprofen). May cause fluid retention, use with caution if you have previously had kidney problems, heart disease, or high blood pressure. Also be careful if you have or previously have had kidney or liver disease, high blood pressure, heart disease or dehydration. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Blood pressure and heart medications called ACE inhibitors (Accupril, Aceon, Altace, Prinivil, Univasc, and Zestril); Blood-thinning drugs (Coumadin); Furosemide (Lasix); Lithium (Lithonate).

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Motrin (Ibuprofen)
Pronounced: MO-trim
Drug Family = Propionic Acid Derivative; Pharmacia

Prescribed for: An NSAID prescribed for the relief of the symptoms of rheumatoid arthritis and osteoarthritis, juvenile arthritis, treatment of menstrual pain, and overall mild to moderate pain. It can be given to children ages 6 moths and up t reduce fever and moderate pain.
How should I take this drug? Take regularly for arthritis. To avoid an upset stomach take with food or a full glass of milk. For the chewable versions of this drug, take with water or other fluid to help absorption.
Over the counter forms: Advil, Motrin IB, Children's Motrin, Motrin Suspension.
Side effects: Abdominal cramps or pain, abdominal discomfort, bloating and gas, constipation, diarrhea, dizziness, fluid retention and swelling, headache, heartburn, indigestion, itching, loss of appetite, nausea, nervousness, rash, ringing in ears, stomach pain, or vomiting.
Special warnings: Peptic ulcers and internal bleeding can occur without warning. Avoid if you have or still have asthma attacks, face and throat swelling, skin eruptions from Aspirin or other NSAID's (Aleve, Naprosyn) or if you have angioedema. May cause vision problems or prolong bleeding. Do not take if you are dehydrated and use with caution if you have kidney or liver disease, high blood pressure, or heart disease (increase water retention). Avoid chewable tablets if you have phenylketonuria, this drug contains phenylalanine. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Blood pressure medications known as ACE inhibitors, including Vasotec and Capoten; Blood-thinning drugs such as Coumadin; Diuretics such as Lasix and HydroDIURIL; Lithium (Lithonate); Methotrexate (Rheumatrex).

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Naprelan (Naproxen)
Drug Family = Arylacetic Acid Derivative; Elan

Same active ingredient as Naprosyn; tablet has a special delivery system for more rapid absorption.
Prescribed for: An NSAID used to relieve mild to moderate pain and menstrual cramps. It is also prescribed for relief of the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis, and for ankylosing spondylitis, tendinitis, bursitis, acute gout, and for juvenile arthritis.
How should I take this drug? If you miss a dose, take again only if you remember within 2 hours of the scheduled time. Otherwise skip dose and return to normal schedule next day.
Side effects: Back pain, flu symptoms, infection, nasal inflammation, sinus inflammation, sore throat, and urinary infection. Perforation, ulceration and bleeding can occur.
Special warnings: Can increase water retention. It also may cause vision problems. Do not take if allergic to Aspirin or Motrin, or have had hives or asthma attacks as a result of taking these or other related drugs. Peptic ulcers and internal bleeding can occur without warning. Do not take with any of the following: ACE inhibitors such as the blood pressure medication Capoten; Antiseizure drugs such as Dilantin; Aspirin; Beta blockers, including blood pressure drugs such as Inderal; Blood thinners such as Coumadin; Certain water pills (diuretics) such as Lasix; Lithium (Lithonate); Methotrexate; Naproxen in other forms, such as Naprosyn; Oral diabetes drugs such as Micronase; Other pain relievers such as aspirin, acetaminophen (Tylenol), and ibuprofen (Motrin); Probenecid (Benemid).

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Naprosyn (Naproxen)
Pronounced: NAP-roe-sin
Drug Family = Arylacetic Acid Derivative; Roche

Prescribed for: An NSAID prescribed for the relief of swelling, inflammation, stiffness and joint pain associated with rheumatoid arthritis, osteoarthritis, juvenile arthritis, ankylosing spondylitis, tendinitis, bursitis, acute gout, menstrual cramps and general mild to moderate pain. Reduces tissue concentration of inflammatory and painful hormones. Available in tablet, liquid or capsule form.
How should I take this drug? Take regularly for arthritis. Take with food and full glass of milk or water to avoid an upset stomach. Do not double up on medication to compensate for a missed does.
Side effects: Abdominal pain, bruising, constipation, difficult or labored breathing, dizziness, drowsiness, headache, heartburn, itching, nausea, ringing in ears, skin eruptions, or swelling due to fluid retention. Contact a doctor if you develop a Fever, kidney failure, vomiting of blood and congestive heart failure.
Special warnings: Ulcers and internal bleeding can occur without warning. Avoid if you have or still have asthma attacks, face and throat swelling, nasal inflammation, or tumors from Aspirin, Anaprox, Anaprox DS, Aleve or other NSAID's. May cause vision problems or prolong bleeding. Use with caution if you have kidney or liver disease, high blood pressure, or heart disease (increase water retention). Side effects may increase or alter when this drug is combined with any of the following: Aspirin; ACE inhibitors such as the blood-pressure drug Zestril; Beta blockers such as the blood-pressure drug Tenormin, Blood-thinning drugs such as Coumadin; Furosemide (Lasix); Lithium (Eskalith, Lithobid); Methotrexate; Naproxen sodium (Aleve, Anaprox); Oral diabetes drugs such as Diabinese and Micronase; Phenytoin (Dilantin); Probenecid (Benemid); Sulfa drugs such as the antibiotics Bactrim and Septra; EC-Naprosyn should not be used with antacids, H2 blockers such as Tagamet, or sucralfate (Carafate).

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Orudis (Ketoprofen)
Pronounced: Oh-ROO-dis
Drug Family = Propionic Acid Derivative; Wyeth

Prescribed for: An NSAID prescribed for the relief of inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis. Also reduces overall pain and menstrual pain.
How should I take this drug? For arthritis relief take regularly. To minimize side effects take with food, full glass of milk or water or with an antacid. Do not take over the counter medications for more than 10 days without seeing your doctor. Do not double up on a dose to compensate for a missed dosage.
Over the counter brands: Actron and Orudis KT used for minor pain and flu-like symptoms, Oruvail (extended release form) for long term relief not sudden and for reducing fever.
Side effects: Abdominal pain, changes in kidney function, constipation, diarrhea, dreams, fluid retention, gas, headache, inability to sleep, indigestion, nausea, or nervousness.
Special warnings: Do not take with Oruvail. Ulcers and internal bleeding can occur without warning. Extended use may cause anemia. Avoid if you have or still have asthma attacks, face and throat swelling, nasal inflammation, or tumors from Aspirin, Anaprox, Anaprox DS, Aleve or other NSAID's. May cause vision problems or prolong bleeding. Use with caution if you have kidney or liver disease, high blood pressure, or heart disease (increase water retention). Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Blood thinners such as Coumadin; Diuretics such as hydrochlorothiazide (HydroDIURIL); Lithium (Lithonate); Methotrexate; Probenecid (the gout medication Benemid).

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Oruvail (Ketoprofen)
Drug Family = Propionic Acid Derivative; Wyeth

Prescribed for: An extended-release form of the drug used to treat the signs and symptoms of rheumatoid arthritis and osteoarthritis over the long term, not severe attacks that come on suddenly.
How should I take this drug? With food, full glass of water or milk or antacid to avoid stomach upsets and minimize side effects.
Side effects: Abdominal pain, changes in kidney function, constipation, diarrhea, dreams, fluid retention, gas, headache, inability to sleep, indigestion, nausea, or nervousness.
Special warnings: Do not take with Orudis. Ulcers and internal bleeding can occur without warning. Extended use may cause anemia. Avoid if you have or still have asthma attacks, face and throat swelling, nasal inflammation, or tumors from Aspirin, Anaprox, Anaprox DS, Aleve or other NSAID's. May cause vision problems or prolong bleeding. Use with caution if you have kidney or liver disease, high blood pressure, or heart disease (increase water retention). Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Blood thinners such as Coumadinl; Diuretics such as hydrochlorothiazide (HydroDIURIL); Lithium (Lithonate); Methotrexate; Probenecid (the gout medication Benemid).

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Relafen (Nabumetone)
Pronounced: REL-ah-fen
Drug Family = Naphthyalkanone; SmithKline

Prescribed for: An NSAID prescribed for the relief of inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis, gout, bursitis, tendinitis, and menstrual cramps. It treats these conditions by reducing tissue concentration of inflammatory and painful hormones. Manufactured in tablet, liquid, or capsule form.
How should I take this drug? Take regularly for arthritis. Can be taken with or without food. Do not double up on a dose to compensate for a missed dosage.
Side effects: Muscle cramps, numbness of the hands or feet, mouth ulcers, rapid weight gain, abdominal pain, constipation, diarrhea, dizziness, fluid retention, gas, headache, indigestion, itching, nausea, rash, or ringing in ears. Contact doctor immediately if you develop symptoms of an allergic reaction such as hives, rashes, intense itching and faintness.
Special warnings: Stomach and intestinal ulcers can occur without warning. Avoid if you have or still have asthma attacks from Aspirin or other NSAID's. Use with caution if you have kidney or liver disease, high blood pressure, heart disease or congestive heart failure. Can cause water retention. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Diuretics such as HydroDIURIL and Lasix; Lithium (Eskalith); Methotrexate.

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Tolectin (Tolmetin Sodium)
Pronounced: toe-LEK-tin
Drug Family = Pyrroleacetic Acid; McNeil

Prescribed for: An NSAID prescribed to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis, Juvenile rheumatoid arthritis, osteoarthritis, Ankylosing spondylitis, Scapulo-humeral periarthritis, Epicondylitis (tennis elbow), and Traumatic synovitis. Used for both acute episodes and for long-term treatment.
How should I take this drug? Take regularly for arthritis. Take with food, full glass of water or milk, or with an antacid to avoid an upset stomach. Avoid lying down or sleeping for 30 minutes after you take Tolectin. Do not double up on a dose to compensate for a missed dosage.
Side effects: Abdominal pain, change in weight, diarrhea, dizziness, gas, headache, heartburn, high blood pressure, indigestion, nausea, stomach and intestinal upset, swelling due to fluid retention, vomiting, or weakness.
Special warnings: Ulcers and internal bleeding can occur without warning. Can cause kidney problems, more prone in those over 65 years, suffer from heart failure or liver disease, or take diuretics. Tolectin may cause a liver disease, contact your doctor if you develop yellow skin and eyes. May cause poor vision or prolong bleeding. Avoid if you have or still have asthma attacks from Aspirin or other NSAID's. Use with caution if you have kidney or liver disease, high blood pressure, or heart disease, this drug can cause water retention. Side effects may increase or alter when this drug is combined with any of the following: Aspirin; Blood thinners such as Coumadin; Carteolol (Cartrol); Diuretics such as Lasix; Glyburide (Micronase); Lithium (Lithonate); Methotrexate.

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Trilisate (Choline Magnesium Trisalicylate)
Pronounced: TRILL-ih-sate
Drug Family = Salicylate; Purdue Fredrick

Prescribed for: A NSAID prescribed for the relief of mild to moderate pain and inflammation associated with osteoarthritis, rheumatoid arthritis, acute painful shoulder, fever and general pain. This drug is used in the long-term management of these diseases and especially for flare-ups of severe rheumatoid arthritis. In children, this medication is prescribed for severe conditions, for instance juvenile rheumatoid arthritis.
How should I take this drug? Take regularly for arthritis. Do not double up on a dose to compensate for a missed dosage.
Side effects: Constipation, diarrhea, heartburn, indigestion, nausea, ringing in the ears, epigastric pain, stomach pain and upset, tinnitis, gastric upset or vomiting. Chances of side effects increase with age.
Special warnings: Use with caution if you have severe or recurring kidney or liver disorder, gastritis, or a stomach or intestinal ulcer. The risk of stomach problems increases if you have alcoholic drinks daily. This increases the risk of stomach problems. Use with caution if you have had an allergic reaction to aspirin. Side effects may increase or alter when the drug is combined with any of the following: Antacids such as Gaviscon and Maalox; Antigout medications; Blood-thinners such as Coumadin; Carbonic anhydrase inhibitors such as acetazolamide (Diamox) used to treat heart failure, the eye condition called glaucoma, and certain convulsive disorders; Diabetes medications such as insulin, Micronase, and Tolinase; Methotrexate, an anticancer drug; Other salicylates used to reduce fever, inflammation, and pain, such as aspirin; Phenytoin (the seizure medication Dilantin); Steroids such as prednisone; Valproic acid (the seizure medication Depakene).

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Vioxx (Rofecoxib)
Pronounced: VYE-ox
Drug Family = COX II Inhibitors; Merck

Prescribed for: A COX-2 inhibitors that relieves pain and inflammation associated with osteoarthritis, rheumatoid arthritis, painful menstruation. This drug as well as other COX-2 inhibitors, limits the effect of a natural enzyme called COX-2. They do not interfere with COX-1, an enzyme that yields a protective effect on the lining of the stomach as the older NSAIDs had. Because of this, Vioxx and other COX-2 inhibitors are less likely to cause the bleeding and ulcers that can occur from the continuous use of older NSAIDs. Does not share the blood-thinning effects of aspirin, it may be necessary to take aspirin in addition to Vioxx.
How should I take this drug? Take regularly for arthritis. Recommended to take with food or water to avoid an upset stomach. Do not double up on a dose to compensate for a missed dosage.
Side effects: Upper respiratory tract infection, diarrhea, nausea, heartburn, swelling of the lower legs or feet, or high blood pressure.
Special warnings: Increased risk of heart attack. May lead to meningitis. Avoid if you have experienced asthma, hives, or allergic-type reactions after taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Use with caution if you have or have had ulcers or stomach bleeding, severe kidney problems, or severe liver problems. Can cause fluid retention. Side effects may increase or alter when the drug is combined with any of the following: aspirin, certain blood pressure medications called ACE-inhibitors; furosemide; lithium; methotrexate; rifampin; warfarin.